Lionheart Health, a regenerative health and longevity technology company, has announced a strategic partnership with Rejuvant, developer of the patented, sustained-release Calcium alpha-ketoglutarate (CaAKG) supplement, as part of Lionheart Health’s participation in the XPRIZE Healthspan Semi-Finals. Lionheart Health was selected as a top 40 semi-finalist out of more than 600 entries in spring 2025.
Under the collaboration, Rejuvant’s CaAKG supplement—associated with peer-reviewed research demonstrating improvements in biological age markers—has been designated a mandatory core component of the Lionheart KLOTHO-UP™ Study and the broader Lionheart Klotho Wellness Program, both central to Lionheart’s XPRIZE Healthspan initiative.
The Lionheart KLOTHO-UP™ Study integrates Rejuvant’s CaAKG supplementation within a multi-modal healthspan optimization framework designed to evaluate coordinated improvements across muscle, metabolic, immune, cardiovascular, and brain health domains. In addition to Rejuvant CaAKG, all study participants receive SNiP Nutrition™ personalized supplements, customized based on genetic and biomarker profiles; targeted Klotho-focused supplementation; and Lionheart Health’s BodStim™ bioelectric exercise platform, which delivers Klotho- and follistatin-elevating electrical muscle stimulation–enhanced exercise sessions (1 hour, 2–3 times per week). This integrated approach reflects Lionheart’s belief that meaningful healthspan extension requires both lifestyle optimization and advanced biological technologies working in concert.
All enrollees in the KLOTHO-UP™ Study and Klotho Wellness Program undergo an extensive testing and evaluation protocol at baseline, 3 months, 6 months, and 12 months, including: a 461-biomarker comprehensive blood panel including klotho levels; AI-enhanced full-body MRI with targeted organ and tissue analysis (optional); muscle health assessments such as grip strength, 6-minute walk, muscle mass index, and gait speed; gut health, immunity strength, and microbiome assessment; breathing and sleep analysis (optional); stress and inflammation profiling including cortisol measurement (optional); blood sugar and metabolic regulation analysis; vascular and calcification assessment (optional); joint health and mobility evaluation (optional); sexual health assessment (optional); vision and hearing evaluation (optional); and brain health testing including cognition, memory, and mood metrics. This longitudinal design enables objective tracking of functional healthspan changes over time rather than reliance on single-endpoint or short-duration outcomes.
“Rejuvant’s CaAKG platform represents one of the most rigorously studied nutritional interventions in the biological aging space,” said a spokesperson for Lionheart Health. “By making CaAKG a mandatory core component of our XPRIZE Healthspan protocol, we are anchoring our program in validated metabolic biology while layering in advanced bioelectric, Klotho-focused, and personalized technologies.”
This partnership highlights the growing emphasis on comprehensive, biomarker-driven approaches to healthspan extension, as competitors in the XPRIZE Healthspan race seek to demonstrate measurable improvements in functional aging.
